James Parkinson first distinguished essential tremor from other tremor disorders (including the disease that carries his namesake) in 1817. Here we are nearly 200 years later, and there are still many unanswered questions about essential tremor. However, researchers are moving our knowledge forward. It is vital to understand what causes ET in order to develop tailored treatment options and even, someday, a cure for this life-altering condition.
The Driving Need for Essential Tremor ResearchBy Ludy Shih, MD
As a clinician investigator, I see two things driving the need for essential tremor research: A) the need for more effective and better tolerated medications for tremor, and B) the ways that the common clinical features of ET should lend us clues to the understanding of tremor. Read more.Imaging the ET BrainBy Fatta B. Nahab, MD
Investigators are using various advanced MRI techniques to compare both the structure and function of ET brains to those without ET. This will help provide answers that may help explain why people have different tremor types or severities, why people have different responses to particular medications, and what role genetics has on the brain. Read more.GABA receptor may present target for new ET drug therapy
By Charles A. Handforth, MD
I now aim to narrow down exactly which combination of delta, alpha, and beta subunits forms the receptor capable of suppressing tremor when activated. I believe that the identification of this receptor could lead to the development of drugs that specifically suppress tremor, yet might be well tolerated. Read more.