IETF Funded Research FY 2011

LINGO Gene Study
A study by the Banner Sun Health Research Institute examines Neuropathological and Biochemical Substrates for Essential Tremor. Dr. Holly Shill, Director, Cleo Roberts Center for Clinical Research, Christopher Center for Parkinson Research, leads this study. The cause of essential tremor (ET) is unknown but recent findings have shown genetic links to the genes LINGO-1 and LINGO-2.

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Study Sheds Light on Drugs’ Potential for Tremor Suppression
A study by Dr. Adrian Handforth and Dr. Arnulfo Quesada has yielded notable results with a potential focus for essential tremor (ET) drug treatment. Funded by a grant from the IETF, the study concerns the impact of five drugs in blocking T-type calcium channels and suppressing tremor in two different models when tested on mice. Drawing from their IETF-supported work, the scientists produced three papers, one of which was published in 2008 in Drug Metabolism and Disposition and another published in 2010 in Neuropharmacology. The third paper has been accepted for publication in the European Journal of Pharmacology.

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