Research Outcomes & Reports

researchmicroscopThe cause of essential tremor must be found, so that better treatment options and a cure can be developed. Research is key. The following articles and reports concern current scientific discoveries and essential tremor research findings.

When reading any research findings, remember that in order for research to be considered valid, it must be repeated and come to the same conclusions.

Essential Tremor in the Elderly and Risk for Dementia 
This study seeks to compare the risk of developing dementia in subjects with ET versus controls without tremor in a large, well-categorized cohort of individuals involved in a longitudinal aging study, the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND).

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INSIGHTEC Submits Pre-Market Application (PMA) for FDA Approval of Exablate Neuro for Treatment of Essential Tremor
PR Newswire – INSIGHTEC, the leader in MR guided Focused Ultrasound (MRgFUS) therapy announces today that it has submitted a pre-market approval application (PMA) to the U.S. Food and Drug Administration (FDA) for its Exablate Neuro treatment of Essential Tremor.

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Defining the Treatment Gap: What Essential Tremor Patients Want That They Are Not Getting
By Elan D. Louis, Brittany Rohl, and Catherine Rice (the IETF’s former Executive Director) – A six-item patient-centeredness questionnaire was devised to assess the self-perceived needs of essential tremor (ET) patients. Patients with ET identified a broad range of issues that they felt were not addressed in their treatment; indeed, only one in 10 patients reported that they were satisfied with their care. It is hoped that patient-centered approaches will lead to improved models for the care of patients with this common chronic disease.

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Abnormal Climbing Fiber-Purkinje Cell Synapses in Essential Tremor (Part 1)
Tremor Talk (September 2015) – Dr. Sheng-Han Kuo’s research team at Columbia University in New York has discovered new features in the cerebellum that may be caused by essential tremor, thanks to an IETF grant issued in 2014.

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Final Report on the Feasibility Study for an Essential Tremor Brain Bank at the Arizona Study of Aging and Neurodegenerative Disorders
Tremor Talk (September 2015) – The brain bank at Banner Sun Health Research Institute in Sun City, AZ was funded by the IETF beginning in 2012, to look at the feasibility of establishing a mechanism to study the clinical features of ET and correlate them with the findings that are seen in the brain at autopsy.

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SAGE Therapeutics Announces Results From Successful Exploratory Trial in Essential Tremor
Globe Newswire – SAGE Therapeutics announced results from a successful exploratory clinical trial of SAGE-547 to evaluate the GABAA mechanism of action as a treatment for essential tremor.

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Comparative effectiveness of propranolol and botulinum for the treatment of essential voice tremor
nih.gov – The objective of this study was to assess the comparative effectiveness of botulinum toxin and propranolol in patients with essential vocal tremor (EVT).

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Isolated vocal tremor as a focal phenotype of essential tremor: a retrospective case review
Journal of Clinical Movement Disorders – Essential tremor (ET) is a common condition associated with significant physical and psychosocial disability. “Classic” ET is a clinical syndrome of action tremor in the upper limbs and less commonly the head, jaw, voice, trunk, or lower limbs. Current diagnostic criteria for ET exclude isolated vocal tremor (IVT). Failure to recognize IVT as a form of ET may contribute to misdiagnosis and missed opportunities for treatment.

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Abnormal climbing fibre-Purkinje cell synaptic connections in the essential tremor cerebellum
Brain (Chi-Ying Lin, Elan D. Louis, Phyllis L. Faust, Arnulf H. Koeppen, Jean-Paul G. Vonsattel and Sheng-Han Kuo) – Structural changes in Purkinje cells have been identified in the essential tremor cerebellum, although the mechanisms that underlie these changes remain poorly understood. Climbing fibres provide one of the major excitatory inputs to Purkinje cells, and climbing fibre-Purkinje cell connections are essential for normal cerebellar-mediated motor control.

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