Research News Archive 2009

ET Genetic Marker Identified
Stefansson, S Steinberg, et al
Reykjavik, Iceland
Researchers found that having a certain genetic marker within the LINGO1 gene significantly increased the odds of having ET. LINGO1 is involved in nerve cell growth, maintenance and survival.

Tremor in One Arm Rare in Inherited ET
F Phibbs, JY Fang, P Hedera, et al
Department of Neurology, Vanderbilt University, Nashville, TN
This study of people from families with ET found that tremor in one arm only is rare, being identified in just 4.4 percent of research participants.

Embarrassment Increases Medication Usage in ET Patients
ED Louis, E Rios
GH Sergievsky Center and Department of Neurology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, and Department of Epidemiology, Columbia University, New York, NY
Recent studies found that embarrassment was responsible for a doubling of tremor medication usage. More than 58% of people in the study reported being embarrassed by their ET, even mild tremor, and women were nearly twice as likely as men to be embarrassed.

ET of the Legs?
KL Poston; E Rios, ED Louis
Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
This study found that mild kinetic (action) tremor of the leg occurred in 44.4 percent of ET cases and in only 14.3 percent of people without ET.

Drug Reduces Tremor
A Handforth, FC Martin, GA Kang, Z Vanek
Department of Neurology, Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA
It was found that the most effective dosage of Zonisamide, an antiseizure medication, per day was approximately 225 to 250 mg. Research participants experienced no additional benefit at dosages of 300 mg or more, but instead experienced more negative side-effects including poor sleep and energy, imbalance, and altered taste.

ET Changes with Age
B Hellwig, P Mund, B Schelter, B Guschlbauer, et al
Neurologische Universitätsklinik, Neurozentrum, Freiburg, Germany
It was found that the tremor frequency – back and forth motions of tremor – decreased with age, but the amplitude – the size or swing of the back and forth motion – increased.

Wearing Wrist Weights Can Reduce Tremor
ME Héroux, G Pari, KE Norman
School of Rehabilitation Therapy, Queen’s University, Ontario, Canada
Although wearing wrist weights increased the amount of neuromuscular activity in the brain, tremor of the arms was reduced. Once a particular heaviness (1 lb, 2lb, etc.) of wrist weight was found that worked in decreasing tremor, a heavier wrist weight did not necessarily lead to greater tremor control.