Research News Archive – 2014

Psychogenic Tremor: A Video Guide to Its Distinguishing Features
By Joseph Jankovic and Mary Ann Thenganatt – While there are numerous studies evaluating psychogenic tremor in the literature, there are no publications that provide a video/visual guide that demonstrate the clinical characteristics of psychogenic tremor. Educating clinicians about psychogenic tremor will hopefully lead to earlier diagnosis and treatment.

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The Non-motor Features of Essential Tremor: A Primary Disease Feature or Just a Secondary Phenomenon?
By Ketan Jhunjhunwala and Pramod K. Pal – Essential tremor (ET) is a pathologically heterogeneous neurodegenerative disorder with both motor and increasingly recognized non-motor features. It is debated whether the non-motor manifestations in ET result from widespread neurodegeneration or are merely secondary to impaired motor functions and decreased quality of life due to tremor.

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How Many People in the United States Have Essential Tremor? Deriving a Population Estimate Based on Epidemiological Data
Elan D. Louis and Ruth Ottman – Using data from three studies, estimates of the number of ET cases (2012) ranged from 6.38 to 7.63 million (mean = 7.01 million). This corresponds to approximately 2.2% of the US population.

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IETF Funds Ground-Breaking Research for 2014
The IETF is excited to fund three new research studies totaling $85,000 this year. These studies are stepping stones to moving our knowledge forward and can provide progress to change the world for everyone with ET.

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Graphene’s potential to reshape neurosurgery
kurzweilai.net – Graphene may lead to exciting new applications in the diagnosis and treatment of neurological diseases, according to a report in the May issue of Neurosurgery, official journal of the Congress of Neurological Surgeons. The paper can also serve as a general introduction to the properties of graphene and its future uses.

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Replacing a defective gene with a correct sequence to treat genetic disorders
kurzweilai.net – The findings, described in the March 30 issue of Nature Biotechnology, offer the first evidence that this gene-editing technique, known as CRISPR, can reverse disease symptoms in living animals. CRISPR, which offers an easy way to snip out mutated DNA and replace it with the correct sequence, holds potential for treating many genetic disorders, according to the research team.

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Researchers identify high levels of certain protein in brains of people suffering from essential tremor
News Medical – A team of researchers from Universit- Laval and CHU de Qu-bec identified unusually high levels of a certain protein in the brains of people suffering from essential tremor (ET), a movement disorder that affects 4% of the adult population. The discovery, the details of which were published in the most recent edition of the journal Movement Disorders, could lead to an effective treatment for this neurological condition, which is 10 times more prevalent than Parkinson’s disease.

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Essential tremor is not associated with cerebellar Purkinje cell loss
There has been controversy as to whether there is an underlying neurodegenerative process of the cerebellum in essential tremor (ET). The aim of this study was to examine whether ET is associated with Purkinje cell (PC) loss. The data from this study demonstrate that ET is not associated with cerebellar PC loss.

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The “Head Snap”: A Subtle Clinical Feature During the Finger–Nose–Finger Maneuver in Essential Tremor
This study reports an interesting movement of the head in patients with ET. This movement, which they have termed the “head snap,” has not been reported previously. Researchers hope that attention to this physical sign will facilitate a more accurate diagnosis of tremor disorders in clinical settings.

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